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Sulfates are the key circulating conjugates of ethinyl estradiol and glucuronides predominate in urine. The key oxidative metabolite is two-hydroxy ethinyl estradiol, fashioned via the CYP3A4 isoform of cytochrome P450. A part of the primary-move metabolism of ethinyl estradiol is thought to manifest in gastrointestinal mucosa. Ethinyl estradiol ma